Publications

Publications serve as the concrete art form for the scientist. It is his modus operandi. Authorship is akin to success and achievement. It cannot and should not deteriorate into a bargaining tool or commodity. Dardik
Van Zyl, R.L., Seatholo, S., Van Vuuren, S.F., Viljoen, A.M. 2006. The biological activities of twenty nature identical essential oil constituents. Journal of Essential Oil Research 18: 129–133.

Twenty nature identical essential oil constituents from seven structural groups were tested for antimalarial, antimicrobial,antioxidant and toxicity properties. The compounds displayed antimalarial activity (IC50 values rangingfrom 0.9 to 1528.8 μM) with varying toxicity (IC50 values ranging from 5.5 to 1358.4 μM). The data indicates that(-)-pulegone, (E- & Z-)-(±)-nerolidol, linalyl acetate and (+)-α-pinene have the most potent antimalaial activity. Carvacrol(MIC values ranging from <1.66 to 13.3 mM) followed by geraniol (MIC values: 19.5-51.9 mM) displayed thebroadest spectrum of antimicrobial activity. The least toxic of the tested compounds, eugenol, was the only compound with antioxidant activity comparable to ascorbic acid. The results demonstrate that the 20 compounds individually display variable biological activity, although further research is required to determine how they may interact when combined.



Publications - TUT, Pretoria, Gauteng, South Africa [2010 © alvaroviljoen.com]