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Viljoen, A.M., Zhou, J., Sandasi, M., Chen, Wei, Khan, I. 2014. Phytochemical distinction between Pelargonium sidoides (“Umckaloabo”) and P. reniforme through H-NMR and UHPLC-MS metabolomic profiling. Metabolomics August 1-9.
Two Pelargonium species which are indigenous to South Africa; P. sidoides DC and P. reniforme Curt., are highly valued traditional remedies used primarily
for the treatment of upper respiratory tract infections. The ethnobotanical
value of P. sidoides has led to the commercialisation
of herbal medicinal products such as Umckaloabo® that are marketed internationally. Although
the two species can be distinguished by leaf shape and flower colour, the
rhizomes which are used for preparation of the commercial extracts are
morphologically similar. Non-targeted 1H-NMR and
UHPLC-MS metabolomic approaches were applied to differentiateP.
sidoides and P. reniforme extracts. qNMR
was used for the quantitative comparison of the marker constituents occurring
in both species. Both 1H-NMR and UHPLC-MS in combination with
multivariate algorithms revealed a chemical distinction between the two species.Umckalin was identified as the marker
compound in P. sidoides (0.0012–0.2760%
(w/w)) by UHPLC-MS, which occurred in trace quantities in P. reniforme (0–0.0016% (w/w)). Conversely, coumarins such as scopoletin,
isofraxoside and a scopoletin isomer were reported to occur in relatively higher levels in P. reniforme compared to P. sidoides.