Publications

Publications serve as the concrete art form for the scientist. It is his modus operandi. Authorship is akin to success and achievement. It cannot and should not deteriorate into a bargaining tool or commodity. Dardik
Viljoen, A.M., Zhou, J., Sandasi, M., Chen, Wei, Khan, I. 2014. Phytochemical distinction between Pelargonium sidoides (“Umckaloabo”) and P. reniforme through H-NMR and UHPLC-MS metabolomic profiling. Metabolomics August 1-9.
Two Pelargonium species which are indigenous to South Africa; P. sidoides DC and P. reniforme Curt., are highly valued traditional remedies used primarily for the treatment of upper respiratory tract infections. The ethnobotanical value of P. sidoides has led to the commercialisation of herbal medicinal products such as Umckaloabo® that are marketed internationally. Although the two species can be distinguished by leaf shape and flower colour, the rhizomes which are used for preparation of the commercial extracts are morphologically similar. Non-targeted 1H-NMR and UHPLC-MS metabolomic approaches were applied to differentiateP. sidoides and P. reniforme extracts. qNMR was used for the quantitative comparison of the marker constituents occurring in both species. Both 1H-NMR and UHPLC-MS in combination with multivariate algorithms revealed a chemical distinction between the two species.Umckalin was identified as the marker compound in P. sidoides (0.0012–0.2760% (w/w)) by UHPLC-MS, which occurred in trace quantities in P. reniforme (0–0.0016% (w/w)). Conversely, coumarins such as scopoletin, isofraxoside and a scopoletin isomer were reported to occur in relatively higher levels in P. reniforme compared to P. sidoides.



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