Publications

Publications serve as the concrete art form for the scientist. It is his modus operandi. Authorship is akin to success and achievement. It cannot and should not deteriorate into a bargaining tool or commodity. Dardik
Drewes, S.E., Mudau, K.E., Van Vuuren, S.F., Viljoen, A.M. 2006. Antimicrobial monomeric and dimeric diterpenes from the leaves of Helichrysum tenax var tenax. Phytochemistry 67: 716–722.

The hexane extract of fresh air-dried leaves of Helichrysum tenax (Asteraceae) afforded ent-beyer-15-en-19-ol (1), its 4-epimer ent-beyer-15-en-18-ol (2), 15β,16β-epoxide-ent-beyeran-19-ol (3), as well as (4) consisting of two units of (1) linked as a diester of malonic acid, and (5), a compound. Its constituents are (1) and (3) also linked as a diester of malonic acid. The leaves of the plant are densely covered in fine glandular trichomes. These are extremely sticky and exude a mixture of the above diterpenes. Antimicrobial tests showed that (1), in particular, was highly active (3.1 and 3.6 μg/ml) against Bacillus cereus and Staphylococcus epidermidis, respectively.



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